B vitamins have been shown to boost energy levels, promote focus, and support a healthy nervous system. This article looks at the top B-complex supplements of 2024, considering factors like formulation, bioavailability, and clinically effective dosages. Here are our top 5 picks. 

​​When choosing a B-complex supplement, keep these five key factors in mind:

1. Contains All 8 Essential B Vitamins: Look for a complete B-complex that includes all eight essential B vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin).

2. Optimal Bioavailability: Check to see if the supplement uses more bioavailable forms of certain B vitamins, such as methylcobalamin for B12 or 5-methyltetrahydrofolate (5-MTHF) for B9. It's even better if the supplement comes in a liquid form rather than a capsule. 

3. Clinically Effective Dosage: Look for supplements with doses that align with scientifically backed amounts for each B vitamin. Be wary of products offering excessive quantities, as some B vitamins (niacin, in particular) can cause adverse effects at very high doses. 

4. No Unnecessary Ingredients: Look for B-complex supplements that are free from unnecessary fillers, artificial colors, or allergens. 

5. Reputable Brand: When choosing a B-complex vitamin, look for brands that follow Good Manufacturing Practices (GMP), conduct independent third-party testing, and make their supplements in the USA. 

NativePath's Vitamin B-Complex stands out in the market for several key reasons. First, it includes all eight essential B vitamins in carefully balanced ratios. This offers synergistic effects and unmatched support for your brain, heart, cells, and energy levels. We also love that this supplement comes in a liquid tincture format. This not only aids in faster absorption but also makes it easier to adjust dosages and is ideal for those who have difficulty swallowing pills. Last but not least, this B-complex comes in a delicious raspberry flavor and is naturally sweetened with monk fruit. This means zero artificial ingredients, zero sugar, and zero fillers. These reasons—paired with NativePath’s incredibly low price (as low as $15 per tincture) and 365-day money-back guarantee—secured NativePath as our #1 choice.

Contains All 8 Essential B Vitamins

Only Available Online

Newly Launched Product (May Sell Out Soon!)

Easy-to-Take Liquid Form

High Dose of B12 (500 mcg)

High Dose of Biotin (400 mcg)

Delicious Raspberry Flavor

Naturally Sweetened with Monk Fruit

Improves Energy Levels

Supports Memory & Focus

Nervous System Support

MTHFR-Friendly

Vegan, Gluten-Free, & Dairy Free

No Fillers or Artificial Ingredients

Optimal Bioavailability

30-Day Supply

Third-Party Tested

cGMP Compliant

Made in the USA

Less Than $1/Serving

Bulk Discounts + Free Shipping

365-Day Money-Back Guarantee

Try it risk-free. No strings attached. 

Country Life's Coenzyme B-Complex offers an extremely potent blend of all eight essential B vitamins. However, since it comes as a capsule and not a liquid, it’s not as bioavailable as our #1 pick. When it comes to formulation, this blend contains 40X more thiamin (B1) and riboflavin (B2) than our #1 pick. While these two vitamins are still considered safe at high doses, some users may experience an upset stomach, nausea, restlessness, numbness, itching, or prickling sensations. Finally, we were impressed to see that this supplement uses a no-flush form of niacin (inositol hexaniacinate). Given its higher niacin concentration (100 mg), this is crucial for preventing allergic reactions like flushing, itching, and rash. With each of these factors in mind, Country Life dropped to #2 on our list of Best B-Complex Supplements of 2025. 

Contains All 8 Essential B Vitamins

Not All Supplements Are Third-Party Tested

High Dose of B12 (500 mcg)

Less Biotin Than Our #1 Pick

No-Flush Niacin (as inositol hexaniacinate)

Exceeds Daily Value of Niacin (625% DV)

Contains Other Complementary Vitamins

Very High Amounts of Thiamine & Riboflavin

Certified Gluten-Free

Less Bioavailable Form (capsule instead of liquid)

Certified Vegetarian

Serving Size Is 2 Large Capsules

2 Month Supply

Certified B Corp

MaryRuth’s Organics was started by a mom of four young kids. So you can be confident that this brand only crafts products that Mary Ruth and her family personally take—ensuring the utmost care and quality. This supplement is great for those with a vitamin B12 deficiency, as it contains a clinically effective dose (1,500 mcg) of B12 per serving. We appreciate that this supplement is naturally flavored, naturally sweetened, and contains zero sugar. However, the cherry flavor and stevia sweetener don’t agree with all tastebuds. Some customers report that it tastes like cherry cough syrup, while others say it’s too sweet. All things considered, MaryRuth Organics’ B Complex Liquid Drops comes in third on our list of Best B-Complex Supplements of 2025.

High Dose of B12 (1,500 mcg)

Doesn’t Contain All 8 Essential B Vitamins

High Dose of Biotin (2,500 mcg)

Only Comes in Cherry Flavor

Low Dose of Niacin (2 mg)

Short Return Policy (30 Days)

Natural Cherry Flavor

Naturally Sweetened with Stevia

2 Month Supply

Clean Label Project Certified

USDA Organic

Gluten-Free, Dairy Free, Non-GMO

cGMP Compliant

Garden of Life’s Raw B-Complex is an all-in-one supplement featuring all eight essential B vitamins, 23 organic fruits and vegetables, and a blend of probiotics and enzymes. Although this supplement was specifically crafted for energy, digestion, and heart health, a handful of loyal customers have recently noticed a decrease in energy levels and an increase in headaches. (This may be attributed to the brand’s recent acquisition by Nestlé and a possible reformulation of the product.) In addition to this, the recommended serving is two capsules daily, which may be unpleasant for those who have a hard time swallowing pills. For this reason, Garden of Life fell to fourth on our list.

Contains All 8 Essential B Vitamins

More Expensive Than Our #1 Pick

23 Organic Fruits & Vegetables

Complaints of a Recent Formula Change

Plus a Probiotic & Enzyme Blend

Gluten-Free, Non-GMO, & Kosher

Less Optimal Dose of Vitamin B12

Third-Party Tested

Exceeds Daily Value of Niacin (281% DV)

2 Month Supply

Carbon Free Certified

Less Bioavailable Form (capsule instead of liquid)

Customer Complaints of Headaches

Complaints of Itchiness & Hives

Serving Size Is 2 Large Capsules

Thorne is known to be a high-quality, well-trusted brand. But they fell short on their Basic B Complex supplement. Just one capsule exceeds the recommended daily intake of vitamin B3 (niacin) by 105 mg. (The upper limit for adults should be 35 mg/day; their formula includes an aggressive 140 mg/serving.) This raises a huge red flag, as high doses of niacin can cause skin flushing, itching, and in rare cases, liver damage. Not only that, but 8 of its 9 ingredients exceed the daily value. This has led to multiple customers complaining about allergic reactions (itching, hives, rash) and tingling in the face and feet. 

Contains All 8 Essential B Vitamins

Extremely High Dose of Niacin (875% DV)

Also Contains Choline

Comes in a Large Capsule

Gluten-Free, Dairy Free, Soy Free

Complaints of Severe Itching, Hives, & Rash

2 Month Supply

Complaints of Tingling in Feet & Face

Less Bioavailable Form (capsule instead of liquid)

Nature Made: Nature Made loves adding unnecessary ingredients to their supplements. The Nature Made Super B Energy Complex capsules include soybean oil, rapeseed lecithin, and carmine (derived from insects). Not only that, but there’s only 6 mcg of vitamin B12 per softgel. For comparison, our top pick has 500 mcg. For these reasons, we recommend avoiding this B-Complex brand.

Life Extension: Hundreds of customers have left reviews sharing their experience with Life Extension’s BioActive Complete B-Complex capsules. They’ve reported swelling of the throat and tongue, itching all over, elevated blood pressure, and a completely red body. The reason why is clear: Eight out of its nine ingredients greatly surpass the daily value (DV) we need. Niacin, in particular, is 6X the amount we need on a daily basis. 

B vitamins are a group of eight essential nutrients that play vital roles in energy production, brain function, cell metabolism, and more. Often referred to as the B-complex vitamins, they include:

1. B1 (Thiamine)
2. B2 (Riboflavin)
3. B3 (Niacin)
4. B5 (Pantothenic Acid)
5. B6 (Pyridoxine)
6. B7 (Biotin)
7. B9 (Folate)
8. B12 (Cobalamin)

Each of these B vitamins is considered “essential,” meaning the body can't produce them on its own. So it’s crucial to replenish them daily through whole foods or supplementation.

Nice to Know: As you begin your vitamin B supplementation, you may notice that your pee is a bright highlighter yellow color. This is normal! This is mainly due to riboflavin (vitamin B2), which intensifies the color of urine. The body is simply excreting any excess B vitamins that it doesn't need. 

That said, because B vitamins are water-soluble and can be excreted through your urine, it’s important to restore them daily through your diet and/or a high-quality supplement.

Fortunately, there are some key indicators that can signal a possible deficiency in certain B vitamins. 

A general B vitamin deficiency typically includes the following symptoms:

• Fatigue and weakness
• Mood changes, including irritability or a low mood
• Cognitive issues, such as poor concentration and memory problems

However, the following symptoms may also arise, depending on the type of B vitamin you’re deficient in…

Nice to Know: Certain groups of people may be more prone to a Vitamin B deficiency…

• Vegans and vegetarians (since B vitamins are primarily found in animal products)
• Older adults (since vitamin B absorption can decrease with age)
• Those with MTHFR gene mutations (which affects folate metabolism)
• Those with certain medical conditions like hypothyroidism, celiac disease, and inflammatory bowel disease (due to impaired B vitamin metabolism or absorption)

By taking a premium B-complex supplement daily, you may experience the following science-backed benefits: 

Improved Energy Levels

Healthy Hair, Skin, & Nails

Reduced Fatigue

Red Blood Cell Formation

Nervous System Support

Enhanced Memory & Focus

Boosted Immune Response

Improved Mood 

To recap, there are seven important criteria to consider when shopping for a B-complex supplement…

1. Full-Spectrum Formulation: Double-check the Supplement Facts Panel to ensure that it has all 8 essential B vitamins. 

2. Liquid Form: Opt for liquid B vitamins over ones that come in a capsule. Liquid vitamins absorb faster, are more usable by the body (bioavailable), and are easier on the digestive system. 

3. Safe Niacin Content: Check the amount of niacin (vitamin B3) in each serving. Ideally, you want no more than 35 mg. 

4. Clean Ingredients: Review the ingredients listed under “Other Ingredients” (this is usually directly underneath the Supplement Facts Panel). You want to make sure it’s free of artificial ingredients, sweeteners, colors, sugars, and fillers. 

5. Effective Dosage: Most people seek out a B-complex supplement to increase their intake of B12, biotin, and folate. Ensure that there are adequate amounts of each of these vitamins. 

6. Bioavailable B Vitamins: Your B-complex supplement should have the most bioavailable forms of each B vitamin. These include the following:

• Vitamin B1: Thiamine HCL
• Vitamin B2: Riboflavin-5'-phosphate (R5P)
• Vitamin B3: Nicotinamide (niacinamide) or Inositol hexanicotinate
• Vitamin B5: D-Pantothenic Acid
• Vitamin B6: Pyridoxine or Pyridoxal-5'-phosphate (P5P)
• Vitamin B7: D-biotin
• Vitamin B9: 5-Methylertrahydrofolate (5-MTHF, or L-methylfolate)
• Vitamin B12: Methylcobalamin

7. MTHFR-Compliant, If Applicable: For those with the MTHFR gene variation, seek out a B-complex supplement that uses methylated forms of B vitamins. These include the following:

• Vitamin B2: Riboflavin-5-phosphate
• Vitamin B3 (Niacin): Niacinamide or inositol hexanicotinate
• Vitamin B6: Pyridoxal-5-phosphate (P5P)
• Vitamin B9 (Folic Acid): Methylfolate (5-MTHF or L-methylfolate)
• Vitamin B12: Methylcobalamin or adenosylcobalamin

+

References

Disclosure       Terms & Conditions       Privacy Policy

The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on the Natural Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

Copyright © 2025 Natural Reviews

END OF WINTER SALE:

Try Our Top Pick!

Get NativePath B-Complex

(+ FREE Shipping)

Try it risk-free. No strings attached.