Probiotics have been shown to improve digestion, bloating, immunity, and more. This article looks at the top probiotic supplements of 2025, considering factors like strain diversity, CFU count, and shelf stability. Here are our top 5 picks. 

​​When choosing a probiotic, keep these five key factors in mind:

1. Strain Diversity: Look for supplements with multiple strains of beneficial bacteria. Some well-studied strains include: Lactobacillus acidophilus (digestive health), Bifidobacterium lactis (immune support), and Lactobacillus rhamnosus (overall gut health).

2. CFU Count: A higher CFU count generally indicates more potent supplements. Aim for at least 1 billion CFUs per serving, though some conditions may require higher doses.

3. Shelf Stability: Check if the product requires refrigeration or is shelf-stable. Shelf-stable products often use freeze-dried bacteria and moisture-resistant packaging.

4. Includes Prebiotics: Some supplements include prebiotics, which feed the probiotics and may enhance their effectiveness. Prebiotics help probiotics colonize the gut more effectively, may improve their survival rate, and offer additional health benefits, such as improved mineral absorption and bowel regularity.

5. Reputable Brand: When choosing a probiotic, look for brands that follow Good Manufacturing Practices (GMP), conduct independent third-party testing, and make their supplements in the USA. 

Only Available ONLINE

10 Unique Super-Strains

2.75 Billion CFUs Per Capsule

Plus, a Prebiotic Blend

Supports Healthy Digestion

Restores Regularity

Eases Gas & Bloating

Safeguards Immunity

No Refrigeration Necessary (Freeze-Dried)

30-Day Supply

Less Than $1/Serving

Third-Party Tested & cGMP Compliant

Made in the USA with Globally-Sourced Ingredients

Bulk Discounts + Free Shipping

365-Day Money-Back Guarantee

NativePath's Probiotic stands out on the market for several reasons. First, it includes 10 well-researched super-strains to improve digestion, reduce bloating, support immunity, and more. NativePath customers can attest to this: They've reported not only regular bowel movements but also less burping, heartburn, and GI pain. We love that this supplement also contains prebiotics. Unlike probiotics (which are live bacteria), prebiotics serve as food for these good bacteria, helping them thrive and maintain a healthy balance in the digestive system. When it comes to potency, NativePath Probiotic features a robust 2.75 billion CFUs per capsule. NativePath also freeze-dries the bacteria, ensuring the supplement doesn't require refrigeration—unlike many other probiotics. These benefits—combined with NativePath's competitive price (as low as $17 per bottle) and generous 365-day money-back guarantee—solidify NativePath as our #1 choice.

Try it risk-free. No strings attached. 

“I have been taking the NativePath Probiotics capsules for approximately three months. Within two weeks of initiating, my constipation and almost daily heartburn, along with bloating were nearly gone! Amazing!!”

—Deborah B., NativePath Verified Customer, 06/11/2023

Customer results have not been independently verified. Individual results may vary.

High CFU Count (60 Billion)

10 Super-Strains

Contains Sunflower Oil

Organic Prebiotic Blend

Over 10,000 Negative Reviews

Third-Party Tested

30-Day Supply

Complaints of Diarrhea & Severe Abdominal Pain

Acid-Resistant Capsules

Shorter Return Policy (60 Days)

Non-GMO Certified

Third-Party Tested

No Refrigeration Necessary

Physician's Choice probiotic supplement offers a potent blend of 60 billion CFU and 10 probiotic strains per capsule, complemented by an organic prebiotic mix for enhanced effectiveness. That said, general gut health maintenance only requires 1 billion CFUs per day, which means this product has 60X that amount. This is likely why there are over 10,000 negative ratings (between 1, 2, and 3 stars) where customers have reported diarrhea, cramps, nausea, bloating, and severe abdominal pain. Some don’t see a change in their digestion at all. While we like that this product is free of gluten and GMOs, we don’t love its inclusion of sunflower oil—a highly processed seed oil that can lead to inflammation in the body. For these reasons, Physician’s Choice dropped to second on our list. 

Extremely High CFU Count (100 billion)

34 Probiotic Strains

Whole-Food Approach 

Not Suitable for Dairy-Free or Vegan Diets

Non-GMO

NSF Certified Gluten-Free

May Cause Nausea, Abdominal Pain, & Diarrhea

No Refrigeration Necessary

Certified B-Corp

Doesn’t Work for Everyone

Complaints of Missing Capsules

Non-Organic Fruit & Veggie Blend

Garden of Life's Raw Probiotics offers a potent blend of 100 billion CFU from 34 probiotic strains. The formula is inspired by traditional fermented foods and includes a protein-digesting enzyme blend along with a raw fruit and veggie blend, aiming to provide a whole-food approach to probiotics. Its high Bifido content may be particularly beneficial for gut health. However, it's not suitable for dairy-free or vegan diets due to its inclusion of yogurt concentrate and kefir. The recent acquisition by Nestle has raised concerns among some consumers, especially those who've experienced side effects or found the product ineffective. Despite its impressive formula, these factors have led to Garden of Life's third-place ranking on our list.

Only One Strain of Probiotics

12 Billion CFU

No Refrigeration Necessary

Very Limited Formula

Affordably Priced

Not Recommended for Those with IBS

2-Month Supply

Doesn’t Work for Everyone

Contains Titanium Dioxide (a potential carcinogen)

Culturelle's probiotic supplement offers a focused, but limited approach with 12 billion CFUs of a single strain, Lactobacillus rhamnosus GG. While known for its digestive and immune benefits, the single-strain formula may not provide as many benefits as multi-strain probiotics. Something else to consider is the addition of chicory root extract—which can trigger IBS symptoms like gas, bloating, and abdominal discomfort in some individuals due to its high content of inulin (a type of soluble fiber and prebiotic). Moreover, the presence of titanium dioxide, a potential carcinogen, in the "Other Ingredients" raises concerns. While popular, Culturelle's limited probiotic profile and potential side effects for sensitive individuals contribute to its fourth-place ranking in our list of Best Probiotic Supplements for 2025.

High AFU Count (53.6 Billion)

Capsule-in-Capsule Design

24 Different Strains

Most Expensive Pick ($60)

Third-Party Tested

Several 1-Star Reviews

30 Day Supply

Doesn’t Work for Everyone

No Refrigeration Necessary

Very High CFU Count

Causes Severe Side Effects for Some

2-Capsule Serving Size

Short Return Policy (30 Days)

Seed is one of the more sophisticated probiotic supplements on the market. Its innovative capsule-in-capsule design is intended to protect the live probiotics from stomach acid and ensure their targeted release in the colon. The outer capsule holds the prebiotics, while the inner capsule holds a diverse blend of 24 clinically studied probiotic strains, totaling 53.6 billion AFU (active fluorescent units). However, at $59.99 for a 30-day supply, it's the most expensive option on our list. Despite its sophisticated formulation, user experiences vary widely. Some report significant digestive improvements, while others experience severe side effects like bloating, constipation, and diarrhea. The high percentage of negative reviews (15% 1-star) suggests it may not be suitable for everyone. While Seed's scientific approach is commendable, the combination of high cost and mixed user experiences contributes to its fifth-place ranking on our list of Best Probiotic Supplements of 2025.

OLLY: Despite being one of the most popular probiotic brands on Amazon, this product falls short in several key ways. First, it only contains 500 million CFUs per serving, which is less than the recommended minimum of 1 billion CFUs for an effective probiotic supplement. Second, it contains only one probiotic strain—Bacillus coagulans MTCC 5856—potentially limiting the range of benefits users may experience. Third, their prebiotic blend includes xylitol, a sugar alcohol that can cause digestive discomfort in some individuals. Lastly, the inclusion of cane sugar is unnecessary in a probiotic supplement and may counteract some of the product's intended benefits.

Align Probiotic: We were surprised to see such a high price tag ($47) for a product so poorly made. Align contains only one probiotic strain (Bifidobacterium 35624) at a concentration of just 10 million CFUs guaranteed until expiration. This is significantly lower than more effective probiotic supplements, which typically contain at least 1 billion CFUs per serving. Moreover, the inclusion of caramel coloring is concerning. The production of this additive can lead to the formation of 4-methylimidazole, a compound identified as a potential carcinogen by the International Agency for Research on Cancer in 2011.

Fermented foods like yogurt, kefir, sauerkraut, and kimchi are natural sources of probiotics. However, modern lifestyles, processed diets, and the use of antibiotics can disrupt our natural microbial balance. As a result, many people turn to probiotic supplements to replenish and support their gut flora, aiming to restore and maintain a healthy digestive system.

By taking a premium probiotic supplement daily, you may experience the following science-backed benefits:

Restores Regularity

Prevents Occasional Constipation

Alleviates Gas & Bloating

Supports Immunity

Supports Mood & Cognition

Improves Nutrient Absorption

Helps Reduce Cravings

Maintains Healthy, Radiant Skin

To recap, there are five important criteria to consider when shopping for a probiotic supplement…

1. Diverse Strain Profile: Check the Supplement Facts Panel to ensure the product contains multiple probiotic strains. A diverse range of strains can provide broader health benefits.
2. Adequate CFU Count: Look for supplements with at least 1 billion CFUs (Colony Forming Units) per serving. Higher CFU counts may be beneficial for specific health concerns.
3. Targeted Formulation: Consider probiotic blends formulated for specific health needs, such as digestive health, immune support, or women's health.
4. Survival Guarantee: Choose products with technology that ensures probiotic survival through stomach acid, such as delayed-release capsules or special coatings.
5. Clean Ingredients: Review the "Other Ingredients" list. Opt for supplements free from unnecessary additives, artificial colors, preservatives, and potential allergens. Also, check for the inclusion of prebiotics, which can enhance probiotic effectiveness.

“I am enjoying the Probiotic. My stomach is getting flatter, which before taking this supplement I had a nice size bulge. I have a monthly subscription which I will continue to obtain. Great Product.”

—B. Jones, NativePath Verified Customer, 04/28/2024

“I used a bottle of this stuff, and it worked well. Since I ran out, I have been reverting back to my pre-use level of bowel movements, not very good.”

—William C., NativePath Verified Customer, 01/26/2024

“The best I’ve tried!”

—Deborah L., NativePath Verified Customer, 01/04/2024

“Probiotic has helped my digestion. I don’t feel bloated after meals like I use to. I try to eat healthy for the most part but there are those times I stray.

Probiotic works!!!”

—Felecia F., NativePath Verified Customer, 12/01/2023

“I have been using the probiotic for 1 week and I am no longer having to take Pepcid everyday for heart burn!”

—Peggy, NativePath Verified Customer, 11/19/2023

“Better than any probiotic I have ever taken”

—Lois G., NativePath Verified Customer, 11/10/2023

“This is the 3rd probiotic I have tried and this particular one, 3rd, has worked as I thought a probiotic should work. I am very pleased with my waste management system now.”

—Tere F., NativePath Verified Customer, 09/30/2023

“This gives me no tummy troubles at all. It has been a monumental part of my treatment.”

—Aubrey L., NativePath Verified Customer, 09/09/2023

“I was suffering from GI issues (extreme burping and bloating) for months. I think it was the start of perimenopause. After a week, I noticed significant improvements. A month later, I feel just about back to normal. Wonderful product! I bought at a discounted rate for a 6 month supply.”

—D.M., NativePath Verified Customer, 08/24/2023

“I have tried several probiotics and this is by far the best product I have tried. It has really helped with my GI pain and symptoms. I am ordering more.”

—P.G., NativePath Verified Customer, 07/28/2023

“I’ve been on Probiotics for about 9 months. I feel stronger and healthier…my immune system is healthier than ever.”

—Susan R., NativePath Verified Customer, 06/24/2023

“Great product and no tummy trouble! I gave a bottle to my husband for GI problems and he thought it made a difference! Thanks for all you do!”

—Linda D., NativePath Verified Customer, 06/15/2023

Customer results have not been independently verified. Individual results may vary.

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The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on the Natural Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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