Natural sleep supplements have been shown to help you fall asleep faster, stay asleep longer, and achieve deeper, uninterrupted sleep—without the habit-forming side effects of popular sleep medications. This article looks at the top 5 natural sleep supplements of 2025, considering factors like ingredient formulation, potential side effects, and safe dosages.

​​When choosing a supplement for sleep, keep these five key factors in mind:

1. Synergistic Ingredients: Look for supplements with well-studied, natural ingredients such as melatonin, magnesium, L-theanine, and valerian root.

2. Safe Dose: Ensure the dosage is appropriate and clinically proven to be effective. For example, melatonin is typically effective in doses between 0.5-5 mg and experts advise not taking more than 5 mg (unless a doctor recommends it).

3. Non-Habit Forming: Opt for supplements that don't cause dependency or have significant side effects. Examples of habit-forming medications to avoid are diazepam (Valium), alprazolam (Xanax), zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Lunesta), and diphenhydramine (Benadryl).

4. Timing: Look for supplements designed for your specific sleep issues. For example, melatonin and L-theanine help you fall asleep, while magnesium and GABA help you stay asleep. 

5. Reputable Brand: When choosing a sleep supplement, look for brands that follow Good Manufacturing Practices (GMP), conduct independent third-party testing, and make their supplements in the USA. 

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4 Science-Backed Sleep Ingredients

Plus 10g of Collagen

Helps You Fall Asleep Faster

Supports Longer Sleep Sessions

Enhances Skin, Hair, & Nails

Gluten-Free & Dairy Free

3 Delicious Flavors

Naturally Sweetened with Monk Fruit

Third-Party Tested

cGMP Compliant

Made in the USA with Globally-Sourced Ingredients

Affordable Pricing (+Bulk Discounts)

365-Day Money-Back Guarantee

NativePath Collagen PM stands out in the market for several key reasons. Not only does it offer a powerful blend of four sleep-promoting ingredients (melatonin, magnesium, GABA, and L-theanine), but it also provides 10 grams of youth-boosting collagen. This unique combination supports deeper, longer sleep while simultaneously restoring your skin, hair, nails, and joints. Available in three delicious flavors—Chocolate, Honey Chamomile, and Lemon—this easily dissolvable powder transforms your bedtime routine into a pleasant ritual. The powder form ensures faster absorption and allows for easy dosage customization, making it ideal for those who dislike swallowing pills before bed. These benefits, coupled with NativePath's exceptional 365-day money-back guarantee, solidify Collagen PM as our #1 choice for sleep supplements in 2025.

Try it risk-free. No strings attached. 

“My husband and I have been using the collagen p.m. for about 2 weeks. He likes the lemon and I love the chocolate! Both of us have had been able to have deeper sleep and stay asleep longer! We are in our 70's and do not want to use sleep medication so we decided to try this.”

—Judy L, NativePath Verified Customer, 03/18/2024

Customer results have not been independently verified. Individual results may vary.

Complaints of Diarrhea & Upset Stomach

High Dose of Magnesium (220 mg)

Customers Report Bad Taste

Vegan, Gluten-Free, Non-GMO

Doesn’t Work for Everyone

Easily Dissolvable Powder

Doesn’t Include Collagen

113 Servings

Less L-Theanine Than Our #1 Pick

Less GABA Than Our #1 Pick

Natural Vitality’s CALM Sleep Drink Mix offers a potent dose of magnesium alongside three other sleep-promoting ingredients: GABA, L-theanine, and melatonin. While magnesium is an essential mineral for the body, there’s just one downside to such a high dose right before bed: some customers have experienced severe diarrhea and stomach pain. When it comes to flavor, this powder comes in Wild Berry. Although it’s naturally flavored and naturally sweetened, dozens of customers have described it as sour and chalky, with a slight fizz. A few customers have even gone so far as to say that they have to force themselves to drink it. With these factors in mind, Natural Vitality came in second on our list of Best Sleep Supplements of 2025.

Very Low Dose of GABA

9 Sleep-Promoting Ingredients

Doesn’t Include Collagen

Encourages a Sense of Calm

Doesn’t Work for Everyone

No Grogginess the Next Morning

Free from Gluten, Dairy, Eggs, & Soy

Complaints of Waking Up During the Night

30-Day Supply

Capsule Form (Less Bioavailable)

Third-Party Tested

Serving Size Is 2 Large Capsules 

cGMP Compliant

Shorter Return Policy Than #1 Pick (90 Days)

Made in the USA with Globally-Sourced Ingredients

This sleep supplement by Primal Harvest is formulated with nine sleep-supporting ingredients: valerian root, tryptophan, GABA, chamomile, lemon balm, hops, lavender, melatonin, and magnesium bisglycinate. While this unique blend may support restorative sleep, the "one-size-fits-all" dosage approach may not be optimal for everyone. Individual needs can vary, and some people require different amounts of certain ingredients for the best effect. Not only that, but this supplement only has 100 mg of GABA and 3 mg of melatonin per serving (whereas our #1 choice had 700 mg of GABA and 5 mg of melatonin). These lower doses may make it harder to fall asleep quickly and achieve uninterrupted sleep, an issue several customers have mentioned in recent reviews. Due to these factors, Primal Harvest has dropped to third on our list of Best Sleep Supplements.

Includes 5-HTP (a precursor to serotonin)

3 g Sugar Per Serving

Contains Xylitol (a sugar alcohol)

Convenient Chewable Tablets

Natural Fruit Flavor

Complaints of Cavities

Certified B Corporation

Doesn’t Include Collagen

ISURAⓇ Verified

Poor Return Policy

Non-GMO

Natural Factors Tranquil Sleep offers a blend of melatonin, L-Theanine, and 5-HTP in a convenient chewable tablet form, potentially improving sleep quality, reducing stress, and regulating mood. The natural fruit flavor makes it more palatable, and its chewable nature may allow for faster absorption compared to traditional pills. However, it's important to note that each serving contains 3 grams of added sugar, which adds up to over 5 cups of sugar annually if taken nightly. Additionally, the supplement contains xylitol, a sugar alcohol that some people may be sensitive to, potentially causing digestive issues like gas or bloating. While the formula shows promise for sleep support, these factors contributed to Natural Factors' placement at fourth on our list of Best Sleep Supplements in 2025.

May Take 1 Month to Notice Results

Contains 4 Different Herbs

Certified Organic

Doesn’t Work for Everyone

Vegan Capsules

Not Third-Party Tested

Gluten-Free, Dairy-Free, Soy-Free

Not Suitable for Pregnant Women (due to ashwagandha)

Ethical Sourcing of Ingredients

Uses a Proprietary Blend

Certified B Corporation

Unknown Amounts of Each Herb

Doesn’t Include Collagen

Capsule Form (Less Bioavailable)

Serving Size Is 2 Large Capsules 

Gaia Herbs SleepThru capsules are formulated with a proprietary blend of organic herbs, including ashwagandha, magnolia bark, passionflower, and jujube date. While this unique combination may help reduce stress and promote relaxation, the exact amounts of each herb are not disclosed, making it difficult to assess their individual effectiveness. Some customers have reported feeling wired or jittery, and waking up several times a night. This could be because herbal supplements often require consistent use over time to show noticeable effects, which may not suit those seeking immediate results. In fact, SleepThru's packaging states, "Best results obtained after 1 month of use." While Gaia Herbs is known for its holistic, organic approach, these factors contributed to SleepThru's placement at the bottom of our list of Best Sleep Supplements for 2025. 

Relaxium: Despite its popularity on Amazon, this sleep supplement falls short in several critical areas:

• Lack of third-party testing: The company doesn't specify that its product undergoes third-party testing, leading to concerns about quality control and safety.
• Questionable product development: There's minimal information available about the purported developer, Dr. Eric Ciliberti, casting doubt on the product's origins and expertise behind its formulation.

• Alarming customer feedback: Approximately 50% of reviews are critical, with numerous customers reporting severe side effects such as: mid-sleep vomiting and diarrhea, prolonged grogginess the following day, and ineffectiveness in improving sleep.

Given these safety concerns and the high rate of negative experiences, we strongly advise avoiding this supplement brand.

By taking a quality sleep supplement daily, you can expect the following science-backed benefits: 

Supports Longer Periods of Uninterrupted Sleep

Helps You Fall Asleep Faster

May Reduce Tossing & Turning

Helps Regulate Sleep-Wake Cycles

Promotes Relaxation Without Drowsiness

Could Be Beneficial for Jet Lag

Promotes Hair Growth & Nail Strength

Reduces Fine Lines & Improves Skin Elasticity

Eases Joint Pain & Enhances Flexibility

Supports Digestive Lining Repair

To recap, there are five important criteria to consider when shopping for a sleep supplement…

1. Look for a combination of melatonin, GABA, L-theanine, and magnesium. This blend can help you fall asleep faster, stay asleep longer, and potentially achieve deeper, more restful sleep.
2. Ensure the supplement contains between 0.5 and 5 mg of melatonin. Doses exceeding 5 mg should be used with caution and under professional guidance.
3. Verify that the supplement is third-party tested and made in a facility that follows Good Manufacturing Practices (GMP).
4. Since individual responses to sleep supplements can vary, choose a brand that offers a generous money-back guarantee. 
5. Double-check the "Other Ingredients" (usually listed below the Supplement Facts Panel) to ensure the product is free from artificial fillers, added sugars, and sugar alcohols.

“I have tried all kinds of sleep aids, nothing worked. Until now, I had my doubts. Twenty-five days, I’ve had three sleepless nights. To me that’s great ! I think the more I get into it, the better it will be.”

—Maryann B., NativePath Verified Customer, 03/03/2024

“This is our 3rd order, we have the drink nightly and experience full nights sleep.”

—Patt B., NativePath Verified Customer, 04/28/2024

“I was pleasantly surprised how good this was. I drink hot or cold with skim milk and it mixes well, not “grainy”. I feel like I’m doing myself a favor with the extra benefits of collagen and the relaxation combined.”

—Marjorie D., NativePath Verified Customer, 05/27/2024

“Really works and makes me fall asleep faster.”

—Joanne K., NativePath Verified Customer, 03/11/2024

“I have recently purchased the collagen sleep aid in chocolate- my favorite flavor. I was doubtful at first, but a pleasantly surprised at how effective it is. As a restless sleeper my whole life, I can honestly say this product surpasses my expectations.”

—Rosanne H., NativePath Verified Customer, 03/04/2024

“We like it because we fall asleep easily now.”

—H.S., NativePath Verified Customer, 03/16/2024

“I suffer from joint pain and also have trouble falling and staying asleep. Since beginning to use this nightly my joints are feeling better and my sleep quality is alot better. Bonus is it tastes like hot chocolate to me. 🙂”

—Crystal H., NativePath Verified Customer, 02/20/2024

Customer results have not been independently verified. Individual results may vary.

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The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on the Natural Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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