Berberine is an impressive natural compound that has been shown to increase GLP-1 production, promote fat breakdown, and support healthy blood sugar. This article looks at the top berberine supplements of 2025, considering factors like ingredient purity, clinically effective dosages, and customer reviews.

As we reviewed each berberine supplement, we considered five important criteria:

1. Features Berberine HCl: Look for supplements that use high-quality berberine HCl (hydrochloride) and are free from unnecessary fillers or additives.

2. Effective Dosage: Ensure the dosage is safe and clinically effective—typically 500-1,500 mg per day, often divided into 2-3 doses. It’s best to start on the lower end (around 500 mg), and work up from there.  

3. Weight Loss Focused: The most effective berberine supplements combine three key ingredients that work together: Berberine HCl activates AMPK and supports GLP-1, Chromium helps regulate insulin sensitivity, and Bitter Melon Extract aids in glucose metabolism. This trio provides comprehensive support for weight management goals.

4. Natural GLP-1 Support: Look for formulations that focus on supporting your body's natural GLP-1 pathways through complementary ingredients. This helps optimize both blood sugar control and appetite regulation naturally.

5. Reputable Brand: When choosing a berberine supplement, look for brands that follow Good Manufacturing Practices (GMP), conduct independent third-party testing, and make their supplements in the USA. 

By NativePath

⭐⭐⭐⭐⭐  90+ 5-star reviews

Only Available ONLINE

500 mg Berberine HCl

Newly Launched Product (May Sellout Soon!)

Promotes Weight Loss

Increases GLP-1 Secretion

Supports Stable Blood Sugar

Helps Improve Cholesterol

100% Vegan, Gluten-Free, & Dairy Free

30-Day Supply

Third-Party Tested for Purity

Made in the USA with Global Ingredients

Bulk Discounts + Free Shipping

365-Day Money-Back Guarantee

Native Berberine stands out in the market for several key reasons. Not only does it offer 500 mg of Berberine HCl per serving, but it also boasts two other powerful ingredients: Chromium and Bitter Melon Extract. These three ingredients work synergistically to support healthy GLP-1 function, optimize metabolism, and promote natural weight loss pathways. This unique formulation sets it apart from many competitors, which often rely on just berberine alone. These benefits, coupled with NativePath's affordable pricing and 365-day money-back guarantee, solidify Native Berberine as our #1 choice for Best Berberine Supplements of 2025.

Try it risk-free. No strings attached. 

“I was pleasantly surprised that it actually works. I’ve lost 7 lbs in one month. My appetite is curbed and truly only eat when hungry. Give these a try.”

—Stephanie J., NativePath Verified Customer, 10/02/2023

Customer results have not been independently verified. Individual results may vary.

“After the first few weeks I already feel way more appetite control and I'm much less hungry. That's a strong sign that my blood sugar is becoming more stable!”

—K., NativePath Verified Customer, 08/07/2023

Customer results have not been independently verified. Individual results may vary.

By Whitaker Nutrition

Double the price of our #1 Pick

500 mg Berberine HCl

Unique 4-in-1 Blend

Less Chromium Than Our #1 Pick

90-Day Money Back Guarantee

Third-Party Tested

Contains 9 Filler Ingredients

cGMP Compliant

Made in the USA

Securing the second spot on our list is GlucoGOLD by Whitaker Nutrition. Developed by the pioneer of alternative medicine, Dr. Julian Whitaker, this unique formula includes 500 mg berberine HCl alongside three other blood sugar-supporting ingredients—cinnamon, banaba, and chromium. With its impressive roster of active ingredients, we were surprised to see that it has nine other “inactive” ingredients…including unnecessary fillers like cellulose, dicalcium phosphate, and glycerin. This, and the steep price ($52/bottle), is what dropped this brand to second place.

By Solaray

Doesn’t Contain Chromium or Bitter Melon

500 mg of Berberine HCl

100% Post-Consumer Recycled (PCR) Bottles

Less Effective Formula for Weight Loss

Committed to Sustainability

Doesn’t Work for Everyone

Affordable Price

cGMP Compliant

Complaints of Nausea & Lightheadedness

Made in the USA 

Vital Extracts Berberine by Solaray offers a solid 500 mg of Berberine HCl per capsule. However, its single-ingredient approach may limit its overall effectiveness for weight loss compared to more comprehensive formulations. The absence of synergistic ingredients like Chromium, which can enhance insulin sensitivity, or Bitter Melon Extract, known for its potential to support glucose metabolism, means users might not experience as pronounced or rapid results in their weight loss journey. For this reason, several customers have expressed that this supplement hasn’t worked for them. Others have complaints of nausea, headaches, and lightheadedness. For these reasons, Solaray dropped to #3 on our list of Best Berberine Supplements of 2025.

By Sports Research

Contains Tree Nuts (Coconut)

500 mg Berberine HCl

Non-GMO

Very Large Softgels

Made with Organic Virgin Coconut Oil

Some Users Report Nausea & Gastrointestinal Distress

cGMP Compliant

Third-Party Tested

Coming in fourth on our list is Sports Research Berberine + Coconut Oil softgels. The addition of organic virgin coconut oil may enhance absorption, which we like. However, some customers complain that the softgels are too large and very hard to swallow. Since the brand recommends taking 2-3 capsules per day, this may be challenging (or nearly impossible) for some people to accomplish.

By NOW

400 mg Berberine HCl

Contains Caramel Coloring

Plus 700 mg MCT Oil

Less Berberine Than Our #1 Pick

cGMP Compliant

Very Large Softgel

100% Post-Consumer Recycled (PCR) Bottles

Free of Gluten, Dairy, & Soy

Squeaking by on our list of Best Berberine Supplements of 2025 is Berberine Glucose Support by NOW. At first glance, this supplement seems promising. It has 400 mg of berberine, plus MCT oil for optimal absorption, and it claims to support healthy glucose levels. But when you look under “Other Ingredients,” you’ll see a surprising addition: caramel color. Some concerns have been raised about certain types of caramel coloring and the potential presence of 4-methylimidazole (4-MEI), a chemical formed during its production that may be linked to an increased risk of cancer.

Berberine is a natural botanical that, just last year, made a resurgence in the natural health scene.

Extracted from flowering plants like European barberry, goldenseal, and Oregon grape, this yellow-colored alkaloid has been used for centuries in traditional medicine to address digestive issues, infections, and inflammation.

Its recent surge in popularity is largely due to its dual-action approach: it can activate AMPK (an enzyme that scientists refer to as our "metabolic master switch") while also supporting natural GLP-1 production in the gut. This combination can influence various aspects of metabolism, including glucose uptake, lipid metabolism, appetite regulation, and energy production. 

And as research progresses, the list of berberine's possible health benefits keeps growing...

By taking a premium berberine supplement daily, you may experience the following science-backed benefits:

Improves LDL (Bad) Cholesterol

More Stable Blood Sugar Through GLP-1 Support

Natural Weight Loss Support

Helps Manage Inflammation 

Improves Gut Health & GLP-1 Production

Reduced Cravings & Better Appetite Control

To recap, there are five important criteria to consider when shopping for a berberine supplement…

1. Check to see that it has at least 500 mg of Berberine HCl per serving.
2. Look for a supplement that also contains chromium and bitter melon for additional weight loss support and blood sugar management.
3. Double-check the “Other Ingredients” section to ensure that it has no fillers or artificial colors.
4. Ensure the supplement is third-party tested and made in the USA.
5. Look at what the company’s guarantee is. It should be at least 90 days so that you can try berberine risk-free. 

“I feel better and I am feeling my clothes get looser! I don’t want to be without this supplement!”

—Linda S., NativePath Verified Customer, 08/19/2023

“I have been using this product for a little over a month and results are great! In fact I have dropped 12 pounds and counting....also sugar levels are dropping.”

—S.G., NativePath Verified Customer, 05/20/2024

“I am very pleased with Nativepath berberine. I have been taking it for three weeks and I see a dramatic reduction in blood sugar spikes after I eat. I no longer have those energy crashes shortly after I eat. I have more energy which allows me to be more active and as a result have lost 5 pounds.”

—Angela L., NativePath Verified Customer, 04/26/2024

“I’ve experienced huge weight fluctuations that made my health journey more difficult. Since taking berberine, I’ve noticed significantly less fluctuations which makes weight loss more consistent vs yo-yoing.”

—Pantea K., NativePath Verified Customer, 04/04/2024

“Helps lower blood sugar immediately. Definitely recommend to everyone.”

—Beth B., NativePath Verified Customer, 09/23/2023

Customer results have not been independently verified. Individual results may vary.

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The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on the Natural Reviews Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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